Background: Different natural and synthetic materials were used for temporary burn wound coverage; however, they are associated with disadvantages including high price which prohibit their widespread use, especially in developing countries. Among all, human amniotic membrane is the only easily available and cost free coverage. Its effects on burn wounds have been studied in this survey.Methods: One-hundred and twenty four patients with 20-50% second and third degree burns and without any other disease were randomly assigned into two groups. The first 61 patients (control group) underwent traditional method of DRESSING with silver sulfadiazine and gauze which were changed twice a day. The remaining 63 patients underwent DRESSING with human amniotic membrane (amnion group), being changed every 3-4 days.Results: Patients in the control group had significantly lower albumin and needed more albumin infusion (231.80±234 gr. versus 111.51±143.82 gr.), received more blood transfusion (1.75± 2.52 bags versus 0.65± 1.18 bags), had significantly more intense pain and so received more narcotics than amnion group (7.97±12.85doses versus 3.84±7.56). Wound infection was higher in the control group (65.66% versus 46.91%) and so was the incidence of sepsis (24.62% versus 6.10%). There was 8.53% mortality in the control group versus 0% in the amnion group. All of the above-mentioned differences were statistically significant.Conclusions: Amniotic membrane DRESSING in deep and more extensive burns leads to better homeostatic, immunologic and local results and because of its low price, its use is strongly recommended.

Background: Active Leptospermum honey has non-peroxide antibacterial and anti-inflammatory effects, rendering it suitable for wound healing. Leptospermum honey is endemic in New Zealand belonging to the manuka bush (Leptospermum scoparium). The objective of the present research was to compare the efficacy of manuka honey DRESSING with conventional DRESSING regarding skin graft donor sites following a burn injury. Methods: This study was carried out in the department of surgery, Iran University of Medical Sciences, Tehran, Iran. It is a noncontrolled prospective trial, and an open-label study, analyzing Leptospermum honey and conventional DRESSING for the treatment of donor site areas for skin grafts. Data were collected from 15 eligible patients with burn wound. Two independent donor sites were formed, one of which was treated with active Leptospermum honey DRESSING and the other covered through the conventional method. Further collected was information regarding subjects’ demographics, self-reported pain (VAS scale), wound surface areas and bacterial wound culture. Results: In the treatment of skin graft donor sites, honey proved to be less painful compared with the conventional group (P=0. 001). Three and seven days following treatment, a significant decrease was observed in the mean wound surface areas in the honey group (P=0. 001). There was no significant difference between honey and conventional DRESSINGs with regards to the rate of infection (20% in honey DRESSING versus 40% in conventional group; P=0. 068). Conclusions: Active Leptospermum honey DRESSING accelerates the healing process, decreases pain and has antimicrobial activity and can be used for care of skin graft donor sites.